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Scanning for Brain Age

A new study opens the door for early detection of Alzheimer�s disease

brain scan

For most patients, a diagnosis of Alzheimer�s disease follows the arrival of many frustrating, irreversible and ultimately debilitating symptoms. A new brain scan developed at the University of California Los Angeles, however, can offer a more accurate method to track brain aging, which could lead to a diagnosis prior to the onset of symptoms.

A new study, published in the January 2009 issue of Archives of General Psychiatry, looked at the brain scans of 76 non-demented volunteers following an injection of FDDNP, a chemical marker that binds to plaque and tangle deposits in the brain.

Researchers were then able to pinpoint where these abnormal protein deposits were accumulating � a response that allowed them to see how and where the brain was aging. Older age correlated with higher concentrations in the areas of the brain involved with memory, where plaques and tangles usually collect. The average age of study volunteers was 67.

�Combining key patient information with a brain scan may give us better predictive power in targeting those who may benefit from early interventions, as well as help test how well treatments are working,� says study author Dr. Gary Small, director of the UCLA Center on Aging.

Thirty-four of the 76 volunteers carried a gene that heightens the risk for developing Alzheimer�s disease.

�We found that for many volunteers, the imaging scans reflected subtle brain changes, which take place before symptoms manifest,� Small says. �This type of scan offers an opportunity to see what is really going on in the brain. We could see more advancing disease in those with mild cognitive impairment, who are already demonstrating some minimal symptoms. Eventually, this imaging method, together with patient information like age, cognitive status and genetics, may help us better manage brain aging.�

Small believes his research opens the window for a future where controlling brain aging will be akin to monitoring high cholesterol or high blood pressure. A brain scan and perhaps a genetic test could predict individual risk, and even medication could be prescribed, if necessary, to prevent or delay mental deterioration. Such an advance would allow doctors to protect a healthy brain before extensive damage occurs.


Matthew M. F. Miller Matthew M. F. Miller, author of “Maybe Baby: An Infertile Love Story” (HCI, 2008), is a syndicated fatherhood blogger

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